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1. Basic information of N-Hydroxysuccinimide (CAS no. 6066-82-6)

N-Hydroxysuccinimide, with its CAS registry number 6066-82-6, has other names like 1-Hydroxy-2,5-pyrrolidinedione; NHS and so on. With the Molecular Formula of C4H5NO3 and Molecular Weight of 115.09, it has the EINECS number of 228-001-3. N-Hydroxysuccinimide is stable under recommended storage conditions, and it is incompatible with strong oxidizing agents, acid chlorides, acid anhydrides, strong bases. When comes to the water solubility, it is soluble in water.

For being one kind of colourless solid, N-Hydroxysuccinimide (NHS) is one organic compound. When comes to its storage, it should be kept in the dry, cool, and well-ventilated place at the temperature of 2-8íŠ, away from light.


2. Properties of N-Hydroxysuccinimide (CAS no. 6066-82-6)

Properties of N-Hydroxysuccinimide (CAS no. 6066-82-6) are as below:
(1)ACD/LogP: -1.711;
(2)# of Rule of 5 Violations: 0;
(3)ACD/LogD (pH 5.5): -1.71;
(4)ACD/LogD (pH 7.4): -1.86;
(5)ACD/BCF (pH 5.5): 1.00;
(6)ACD/BCF (pH 7.4): 1.00;
(7)ACD/KOC (pH 5.5): 2.78;
(8)ACD/KOC (pH 7.4): 2.01;
(9)#H bond acceptors: 4;
(10)#H bond donors: 1;
(11)#Freely Rotating Bonds: 1;
(12)Polar Surface Area: 57.61;
(13)Index of Refraction: 1.6;
(14)Molar Refractivity: 23.865 cm3;
(15)Molar Volume: 69.761 cm3;
(16)Polarizability: 9.461 10-24cm3;
(17)Surface Tension: 88.9209976196289 dyne/cm;
(18)Density: 1.65 g/cm3;
(19)Flash Point: 112.519 centigrade ;
(20)Enthalpy of Vaporization: 58.095 kJ/mol;
(21)Boiling Point: 262.438 centigrade at 760 mmHg;
(22)Vapour Pressure: 0.0020000000949949 mmHg at 25 centigrade.


3. N-Hydroxysuccinimide chemical structure (CAS no. 6066-82-6)

You could convert the following data to obtain N-Hydroxysuccinimide chemical structure:
2). Std. InChI:InChI=1S/C4H5NO3/c6-3-1-2-4(7)5(3)8/h8H,1-2H2


4. Safety information of N-Hydroxysuccinimide (CAS no. 6066-82-6)

For being irritating to eyes, respiratory system and skin, N-Hydroxysuccinimide may cause inflammation to the skin or other mucous membranes. If inhalation, N-Hydroxysuccinimide may cause respiratory tract irritation, and you are advised to move person into fresh air, and if not breathing, give artificial respiration; If ingestion, it may be harmful, and you should rinse mouth with water; If absorbed through skin, N-Hydroxysuccinimide may cause skin irritation, and you should wash off with soap and plenty of water; If contact with eyes, it may cause eye irritation, and you should flush eyes with water as a precaution.


5. Production of N-Hydroxysuccinimide

Succinic acid anhydride could react to product N-Hydroxysuccinimide, and this reaction could happen in the temperature of 160 íŠ, with the reagent of hydroxylamine.


6. The usage of N-Hydroxysuccinimide (CAS no. 6066-82-6)

N-Hydroxysuccinimide could be applied in different fields:
1). Applied as the pharmaceutical intermediate, in the production of semisynthetic kanamycin.
2). Used in the semi-synthesis antibiotics intermediates.
3). Applied in the synthesis of amino acid protective agent.
4). In the synthesis of MAEM and peptide.

As to other uses, being an ester, N-Hydroxysuccinimide (CAS no. 6066-82-6) product could also be applied in in cosmetics and beauty products, as it could activate the elimination of blood originated pigments responsible for dark color and inflammation

And in the chemical field, N-hydroxysuccinimide (NHS) is being one chemical used to form semi-stable, but reactive, esters from carboxylic acids. And the following reaction process explain this clearly:

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